Your heating system should leave on constant, and the room stat turned down to 10 degrees.
That way if the weather becomes unseasonably cold, the house will maintain a reasonable minimum temperature. All radiator valves should be left open. This is because a TRV (Thermostatic Radiator Valve) that has been switched off for six months might become stuck, which would result in the radiator not working when the heating turned back on.
If you have an old boiler (not condensing) it is important to let the boiler circulate at least once a week. This is to let the pump run and make sure it does not seize up. Feel free to get in touch should you require boiler repairs or servicing.